Selected bibliography

ANAESTHESIOLOGY

Ahonen J, Olkkola K, Salmenperä M, Hynynen M, Neuvonen PJ: Effect of diltiazem on midazolam and alfentanil disposition in patients undergoing coronary artery bypass grafting. Anesthesiology 85: 1246-1252, 1996.

Backmann M, Laakso E, Niemi L, Rosenberg PH, Pitkänen M: Intrathecal infusion of bupivacaine with or without morphine for postoperataive analgesia after hip and knee arthroplasty. Br J Anaesth 78: 666-670, 1997.

Heinonen PO, Jousela IT, Blomqvist KA, Olkkola KT, Takkunen OS: Validation of air tonometric measurement of gastric regional concentrations of CO2 in critically ill septic patients. Intensive Care Med 23: 524-529, 1997.

Heiskanen T, Kalso E: Controlled-release oxycodone and morphine in cancer related pain. Pain 73: 37-45, 1997.

Heiskanen T, Olkkola KT, Kalso E: Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone. Clin Pharmacol Ther 64: 603-611, 1998.

Jalkanen L, Rautoma P, Taivainen T, Meretoja O: The pharmacodynamics of mivacurium preceded by atracurium or cisatracurium in children. Anesth Analg 86: 62-65, 1998.

Jalonen J, Hynynen M, Kuitunen A, Heikkilä H, Perttilä J, Salmenperä M, Valtonen M, Aantaa R, Kallio A: Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Anesthesiology 86: 331-345, 1997.

Kalso E, Heiskanen T, Rantio M, Rosenberg PH, Vainio A: Epidural and subcutaneous morphine in the management of cancer pain: a double-blind cross-over study. Pain 67: 443-449, 1996.

Kalso E, Tramer MR, Carroll D, McQuay HJ, Moore RA: Pain relief from intra-articular morphine after knee surgery: a qualitative systematic review. Pain 71: 127-134, 1997.

Koivusalo A-M, Kellokumpu I, Scheinin M, Tikkanen I, Mäkisalo H, Lindgren L: A comparison of gasless mechanical and conventional carbon dioxide pneumoperitoneum methods for laparoscopic cholecystectomy. Anesth Analg 86: 153-158, 1998l

Kyttä J, Tanskanen P, Randell T: Comparison of the effects of controlled ventilation with 100% oxygen, 50% oxygen in nitrogen, and 50% oxygen in nitrous oxide on responses to venous air embolism in pigs. Br J Anaesth 77: 658-661, 1996.

Meretoja OA, Taivainen T: Neuromuscular monitoring. In: Atlas of Anesthesia (Ed. R.D. Miller): Preparation and Intraoperative Monitoring, Churchill Livingstone, Philadelphia, 1997; 1300-1311.

Michelsen LG, Salmenperä M, Hug CC Jr, Szlam F, Van der Meer D: Anesthetic potency of remifentanil in dogs. Anesthesiology 84: 865-872, 1996.

Olkkola KT, Ahonen J, Neuvonen PT: The effect of the systemic antimycotics, itroconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam. Anesth Analg 82: 511-516, 1996.

Raeder J, Korttila K: Regional anaesthesia for day surgery. International Practice of Anaesthesia, vol. 2. Butterworth-Heineman, London. 1996: 1-8.

Rintala E, Seppälä O-P, Kotilainen P, Pettilä V, Rasi V: Protein C in the treatment of coagulopathy in meningococcal disease. Crit Care Med 26: 965-968, 1998.

Salmenperä M, Szlam F, Hug C Jr.: Anestetic and hemodynamic interactions of dexmedetomidine and fentanyl in dogs. Anesthesiology 80: 837-846, 1994.

Tallgren M, Olkkola KT, Seppälä T, Höckerstedt C, Lindgren L: Pharmacokinetics and ventilatory effects of oxycodone before and after liver transplantation. Clin Pharmacol Ther 61: 655-661, 1997.

Tammisto T, Olkkola KT: Dependence of the adequacy of muscle relaxation on the degree of neuromuscular block and depth of enflurane anesthesia during abdominal surgery. Anesth Analg 1995;80:543-547.

Tasmuth T, Estlander A-M, Kalso E: Effect of present pain and mood on the memory of past postoperative pain in women treated surgically for breast cancer. Pain 68: 343-347, 1996.

Tasmuth T, von Smitten K, Kalso E: Pain and other symptoms during the first year after radical and conservative surgery for breast cancer. Br J Cancer 74: 2024-2031, 1996.

Tiainen P, Rosenberg PH: Hepatocellular integrity during and after isoflurane and halothane anaesthesia in surgical patients. Br J Anaesth 77: 744-747, 1996.

Vainio A, Ollila J, Matikainen E, Rosenberg P, Kalso E: Driving ability in cancer patients receiving long-term morphine analgesia. Lancet 346: 667-670, 1995.

Yli-Hankala A, Edmonds H, Heine M, Strickland T, Tsueda K: Auditory steady-state response, upper facial EMG, EEG and heart rate as predictors of movement during isoflurane-nitrous oxide anaesthesia. Br J Anaesth 73: 174-179, 1994.



CLINICAL CHEMISTRY

Adlercreutz, Herman & Gorbach, Sherwood & Goldin, Barry & Woods, Margo & Dwyer, Johanna & Hämäläinen, Esa
Estrogen metabolism and excretion in oriental and caucasian women.
Journal of the national cancer institute 86 (1994) : 14 s. 1076-1082, imp.: 7.454

Adlercreutz, Herman & Fotsis, Theodore & Kurzer, Mindy S. & Wähälä, Kristiina & Mäkelä, Taru & Hase, Tapio
Isotope dilution gas chromatographic-mass spectrometric method for the determination of unconjucated lignads and isoflavonoids in human feces, with preliminary results in omnivorous and vegetarian women.
Analytical biochemistry 225 (1995) s. 101-108, imp.: 2.017

Zhang, Jie-Xiang & Lundin, Eva & Hallmans, Göran & Adlercreutz, Herman & Andersson, Henrik & Bosaeus, Ingvar & Åman, Per & Stenling, Roger & Dahlgren, Sven
Effect of rye bran on excretion of bile acids, cholesterol, nitrogen, and fat in human subjects with ileostomies1-3.
American journal of clinical nutrition 59 (1994) s. 389-394, imp.: 3.144

Lampe, Johanna & Martini, Margaret & Kurzer, Mindy & Adlercreutz, Herman & Slavin, Joanne
Urinary lignan and isoflavonoid excretion in premenopausal women consuming flaxseed powder1-3.
American journal of clinical nutrition 60 (1994) s. 122-128, imp.: 3.144

Griffiths, K. & Adlercreutz, Herman & Boyle, P. & Denis, L. & Nicholson, R. I. & Morton, M. S.
Nutrition and cancer.
Isis Medical Media 1996, pp.173

Fotsis, Theodore & Pepper, Michael S. & Aktas, Erkan & Breit, Stephen & Rasku, Sirpa & Adlercreutz, Herman & Wähälä, Kristiina & Montesano, Roberto & Schweigerer, Lothar
Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis.
Cancer research 57 (1997) s. 2916-2921, imp.: 8.958

Adlercreutz, Herman & Mazur, Witold
Phyto-oestrogens and Western diseases: [Review].
Annals of medicine 29 (1997) s. 95-120, imp.: 1.716

Michnovicz, Jon J. & Adlercreutz, Herman & Bradlow, H. Leon
Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans.
Journal of the national cancer institute 89 (1997) : 10 s. 718-723, imp.: 10.328

Tikkanen, Matti J. & Wähälä, Kristiina & Ojala, Sirpa & Vihma, Veera & Adlercreutz, Herman
Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance.
Proceedings of the National Academy of Sciences of the United States of America 95 (1998) s. 3106-3110, imp.: 9.04

Tikkanen, Heikki & Näveri, Hannu & Härkönen, Matti
Alteration of regulatory enzyme activities in fast-twitch and slow-twitch muscles and muscle fibres in low-intensity endurance-trained rats.
European journal of applied physiology and occupational physiology 70 (1995) s. 281-287, imp.: 0.919

Tikkanen, Heikki O. & Näveri, Hannu & Härkönen, Matti & Tikkanen, Heikki
Skeletal muscle fiber distribution influences serum high-density lipoprotein cholesterol level.
Atherosclerosis 120 (1996) s. 1-5, imp.: 3.095

Aromaa, Arpo & Kosunen, Timo & Knekt, Paul & Maatela, Jouni & Teppo, Lyly & Heinonen, Olli P. & Härkönen, Matti & Hakama, Matti
Circulating anti-Helicobacter pylori immunoglobulin A antibodies and low serum pepsinogen I level are associated with increased risk of gastric cancer.
American journal of epidemiology 144 (1996): 2 s. 142-149, imp.: 3.712

Näveri, Hannu & Leinonen, Hannu & Kiilavuori, Kai & Härkönen, Matti
Skeletal muscle lactate accumulation and creatine phosphate depletion during heavy exercise in congestive heart failure: cause of limited exercise capacity?.
European heart journal 18 (1997) s. 1937-1945, imp.: 1.682

Heiskanen, Mervi & Syvänen, Ann-Christine & Siitari, Harri & Laine, Sinikka & Palotie, Aarno
A novel method to quantitate methylation of specific genomic regions.
PCR methods and applications 4 (1994) s. 26-30, imp.: 4.155

Kämäräinen, Meerit & Riittinen, Leena & Seppälä, Markku & Palotie, Aarno & Andersson, Leif C.
Progesterone-associated endometrial protein - a constitutive marker of human erythroid precursors.
Blood : the journal of hematology 84 (1994) : 2 s. 467-473, imp.: 8.12

Mikkola, Hanna & Syrjälä, Martti & Rasi, Vesa & Vahtera, Elina & Hämäläinen, Eija & Peltonen, Leena & Palotie, Aarno
Deficiency in the a-subunit of coagulation factor XIII: two novel point mutations demonstrate different effects on transcript levels.
Blood : the journal of hematology 84 (1994) : 2 s. 517-525, imp.: 8.12

Rytkönen, E. M. K. & Halila, R. & Laan, Maris & Saksela, Mika & Kallioniemi, Olli-Pekka & Palotie, Aarno & Raivio, Kari
The human gene for xanthine dehydrogenase (XDH) is localized on chromosome band 2p22.
Cytogenetics and cell genetics 68 (1995) s. 61-63, imp.: 4.115

Laan, Maris & Grön-Virta, Kristiina & Salo, Armi & Aula, Pertti & Peltonen, Leena & Palotie, Aarno & Syvänen, Ann-Christine
Solid-phase minisequencing confirmed by FISH analysis in determination of gene copy number.
Human genetics 96 (1995) s. 275-280, imp.: 2.666

Heiskanen, Mervi & Hellsten, Elina & Kallioniemi, Olli-Pekka & Mäkelä, Tomi P. & Alitalo, Kari & Peltonen, Leena & Palotie, Aarno
Visual mapping by fiber-FISH.
Genomics 30 (1995) s. 31-36, imp.: 5.433

Tenhunen, Kai & Laan, Maris & Manninen, Tuula & Palotie, Aarno & Peltonen, Leena & Jalanko, Anu
Molecular cloning, chromosomal assignment, and expression of the mouse aspartylglucosaminidase gene.
Genomics 30 (1995) s. 244-250, imp.: 5.433

Visakorpi, Tapio & Hyytinen, Eija & Koivisto, Pasi & Tanner, Minna & Keinänen, Riitta & Palmberg, Christian & Palotie, Aarno & Tammela, Teuvo & Isola, Jorma & Kallioniemi, Olli-Pekka
In vivo amplification of the androgen receptor gene and progression of human prostate cancer.
Nature genetics 9 (1995) s. 401-406, imp.: 19.844

Mäkelä, Tomi P. & Hellsten, Elina & Vesa, Jouni & Hirvonen, Harri & Palotie, Aarno & Peltonen, Leena & Alitalo, Kari
The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein.
Oncogene 11 (1995) s. 2699-2704, imp.: 6.991

Palotie, Aarno & Heiskanen, Mervi & Laan, Maris & Horelli-Kuitunen, Nina
High-resolution fluorescence in situ hybridization: a new approach in genome mapping.
Annals of medicine 28 (1996) s. 101-106, imp.: 1.129

Kaukonen, Jaakko & Alanen-Kurki, Leena & Jalkanen, Markku & Palotie, Aarno
The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p.
Human genetics 99 (1997) s. 295-297, imp.: 2.455

Chilov, Dmitri & Kukk, Eola & Taira, Suvi & Jeltsch, Michael & Kaukonen, Jaakko & Palotie, Aarno & Joukov, Vladimir & Alitalo, Kari
Genomic organization of human and mouse genes for vascular endothelial growth factor C.
Journal of biological chemistry 272 (1997): 40 s. 25176-25183, imp.: 7.452

Klockars, Tuomas & Isosomppi, J. & Laan, Maris & Kakko, N. & Palotie, Aarno & Peltonen, Leena
The visual assignment of genes by fiber-fish: BTF3 protein homologue gene (BTF3) and a novel pseudogene of human RNA helicase A (DDX9P) on 13q22.
Genomics 44 (1997) s. 355-357, imp.: 3.666

Mikkola, Hanna & Muszbek, Laszlo & Haramura, Gizela & Hämäläinen, Eija & Jalanko, Anu & Palotie, Aarno
Molecular mechanisms of mutations in factor XIII A-subunit deficiency: in vitro expression in COS-cells demonstrates intracellular degradation of the mutant proteins.
Thrombosis and haemostasis 77 (1997) s. 1068-1072, imp.: 4.267

Bono, Petri & Salmi, Marko & Smith, David J. & Leppänen, Ilona & Horelli-Kuitunen, Nina & Palotie, Aarno & Jalkanen, Sirpa
Isolation, structural characterization, and chromosomal mapping of the mouse vascular adhesion protein-1 gene and promoter.
Journal of immunology 161 (1998) s. 2953-2960, imp.: 6.937

Visapää, Ilona & Fellman, Vineta & Varilo, Teppo & Palotie, Aarno & Raivio, Kari & Peltonen, Leena
Assignment of the locus for a new lethal neonatal metabolic syndrome to 2q33-37.
American journal of human genetics 63 (1998) s. 1396-1403, imp.: 10.244

Mäkelä-Bengs, Päivi & Järvinen, Niklas & Vuopala, Katri & Somala Suomalainen, Anu & Ignatius, Jaakko & Sipilä, Mari & Herva, Riitta & Palotie, Aarno & Peltonen, Leena
Assignment of the disease locus for lethal congenital contracture syndrome to a restricted region of chromosome 9q34, by genome scan using five affected individuals.
American journal of human genetics 63 (1998) s. 506-516, imp.: 10.224

Pohjonen, Hanna & Nikkinen, Päivi & Sipilä, O. & Launes, Jyrki & Salli, Eero & Salonen, Oili & Karp, P. & Ylä-Jääski, J. & Katila, T. & Liewendahl, Kristian
Registration and display of brain SPECT and MRI using external markers.
Neuroradiology 38 (1996) s. 108-114, imp.: 0.9

Kairemo, Kalevi J. A. & Tenhunen, Mikko & Jekunen, Antti
Dosimetry of radionuclide therapy using radiophosphonated antisense oligodeoxynucleotide phosphorothioates based on animal pharmacokinetic and tissue distribution data.
Antisense & nucleic acid drug development 6 (1996) s. 215-220, imp.: 4.484

Leppälä, Jaana & Kallio, Merja & Nikula, T. & Nikkinen, Päivi & Liewendahl, Kristian & Jääskeläinen, Juha & Savolainen, S. & Gylling, Helena & Hiltunen, J. & Callaway, J. & Kahl, S. & Färkkilä, Markus
Accumulation of 99mTc-low-density lipoprotein in human malignant glioma.
British journal of cancer 71 (1995) 383-387, imp.: 2.893

Pitkänen, Elja & Pitkänen, Olli & Uotila, Lasse
Enzymatic determination of unbound D-mannose in serum.
Journal of clinical chemistry and clinical biochemistry 35 (1997) : 10 s. 761-766, imp.: 0.968

Syrjälä, Martti & Ruutu, Tapani & Jansson, Sten-Erik
A flow cytometric assay of CD34-positive cell populations in the bone marrow .
British journal of haematology 88 (1994) s. 679-684, imp.: 2.976

Venesmaa, Pekka & Lehtovirta, Pekka & Stenman, Ulf-Håkan & Leminen, Arto & Forss, Matti & Ylikorkala, Olavi
Tumour-associated trypin inhibitor (TATI): comparison with CA125 as a preoperative prognostic indicator in advanced ovarian cancer.
British journal of cancer 70 (1994) s. 1188-1190, imp.: 2.893

Carpelan-Holmström, Monika & Haglund, Caj & Lundin, Johan & Alfthan, Henrik & Stenman, Ulf-Håkan & Roberts, Peter
Independent prognostic value of preoperative serum markers CA 242, specific tissue polypeptide antigen and human chorionic gonadotrophin beta, but not of cardinoembryonic antigen or tissue polypeptide antigen in colorectal cancer.
British journal of cancer 74 (1996) s. 925-929, imp.: 3.188

Halme, Leena & Edgren, Johan & Turpeinen, Ursula & von Smitten, Karl & Stenman, Ulf-Håkan
Urinary excretion of iohexol as a marker of disease activity in patients with inflammatory bowel disease.
Scandinavian journal of gastroenterology 32 (1997) s. 148-152, imp.: 1.717

Vuento, Maarit H. & Stenman, Ulf-Håkan & Pirhonen, Jouko P. & Mäkinen, Juha I. & Laippala, Pekka J. & Salmi, Tuula
Significance of a single CA 125 assay combined with ultrasound in the early detection of ovarian and endometrial cancer.
Gynecologic oncology 64 (1997) s. 141-146, imp.: 1.552

Sorsa, Timo & Salo, Tuula & Koivunen, Erkki & Tyynelä, Jaana & Konttinen, Yrjö T. & Bergmann, Ulrich & Tuuttila, Ari & Niemi, Elina & Teronen, Olli & Heikkilä, Pia & Tschesche, Harald & Leinonen, Jari & Osman, Sirpa & Stenman, Ulf-Håkan
Activation of type IV procollagenases by human tumor-associated trypsin-2.
Journal of biological chemistry 272 (1997) : 34 s. 21067-21074, imp.: 7.452

Salonen, Riitta & Turpeinen, Ursula & Kurki, Laina & Lappalainen, Mari & Ämmälä, Pirkko & Hiilesmaa, Vilho & Teramo, Kari & Koskull, Harriet von & Gahmberg, Nina & Stenman, Ulf-Håkan
Maternal serum screening for Down's syndrome on population basis.
Acta obstetricia et gynecologica Scandinavica 76 (1997) s. 817-821, imp.: 0.872

Korhonen, Juha & Alfthan, Henrik & Ylöstalo, Pekka & Veldhuis, Johannes & Stenman, Ulf-Håkan
Disappearance of human chorionic gonadotropin and its alpha- and beta-subunits after term pregnancy.
Clinical chemistry 43 (1997) : 11 s. 2155-2163, imp.: 3.422

Konttinen, Yrjö T. & Halinen, Sirkka & Hanemaaijer, Roeland & Sorsa, Timo & Hietanen, Jarkko & Ceponis, Arnoldas & Xu, Jing-Wen & Manthorpe, Rolf & Whittington, Joy & Larsson, Åke & Salo, Tuula & Kjeldsen, Lars & Stenman, Ulf-Håkan & Eisen, Arthur
Matrix metalloproteinase (MMP)-9 type IV collagenase/gelatinase implicated in the pathogenesis of Sjögren's syndrome.
Matrix biology 17 (1998) : 5 s. 335-347, imp.: 1.901

Adlercreutz, Herman
Fotsis, Theodore & Zhang, Youming & Pepper, Michael & Adlercreutz, Herman & Montesano, Roberto & Nawroth, Peter Paul & Schweigerer, Lothar
The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and supresses tumor growth.
Nature 368 (1994) : 17 s. 237-239, imp.: 22.326

Attalla, Hesham
Attalla, Hesham & Westberg, Johan A. & Andersson, Leif C. & Adlercreutz, Herman & Mäkelä, Tomi P.
2-methoxyestradiol-induced phosphorylation of Bcl-2: uncoupling from JNK/SAPK activation.
Biochemical and biophysical research communications 247 (1998) s. 616-619, imp.: 2.671

Carson, Marion
Loukovaara, Mikko & Carson, Marion & Adlercreutz, Herman
Regulation of sex-hormone-binding globulin production by endogenous estrogens in vitro.
Biochemical and biophysical research communications 206 (1995) : 3 s. 895-901, imp.: 3.312

Hautanen, Aarno
Hautanen, Aarno & Lankinen, Laura & Kupari, Markku & Jänne, Olli & Adlercreutz, Herman & Nikkilä, Heli & White, Perrin
Associations between aldosterone synthase gene polymorphism and the adrenocortical function in males.
Journal of internal medicine 244 (1998) : 1 s. 11-18, imp.: 2.382

Loukovaara, Mikko
Loukovaara, Mikko & Carson, Marion & Adlercreutz, Herman
Regulation of production and secretion of sex hormone-binding globulin in HepG2 cell cultures by hormones and growth factors.
Journal of clinical endocrinology and metabolism 80 (1995) : 1 s. 160-164, imp.: 4.22

Wang, Guojie J. & Lusa, Katariina & Talme, Marjot
Adlercreutz, Herman & Wang, Guojie J. & Lapcik, Oldrich & Hampl, Richard & Wähälä, Kristiina & Mäkelä, Taru & Lusa, Katariina & Talme, Marjot & Mikola, Heikki
Time-resolved fluoroimmunoassay for plasma enterolactone.
Analytical biochemistry 265 (1998) 208-215, imp.: 2.017

Mazur, Witold
Mazur, Witold & Fotsis, Theodore & & Wähälä, Kristiina & Ojala, Sirpa & Salakka, Auli & Adlercreutz, Herman
Isotope dilution gas chromatographic-mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples.
Analytical biochemistry 233 (1996) s. 169-180, imp.: 2.017

Härkönen, Matti &Honkanen (Sande), Niina
Ristimäki, Ari & Honkanen, Niina & Jänkälä, Heidi & Sipponen, Pentti & Härkönen, Matti
Expression of cyclooxygenase-2 in human gastric carcinoma.
Cancer research 57 (1997) s. 1276-1280, imp.: 8.958

Jänkälä, Heidi & Harjola, Veli-Pekka
Jänkälä, Heidi & Harjola, Veli-Pekka & Petersen, Niels Erik & Härkönen, Matti
Myosin heavy chain mRNA transform to faster isoforms in immobilized skeletal muscle: a quantitative PCR study.
Journal of applied physiology 82 (1997) : 3 s. 977-982, imp.: 2.05

Mäki, Tiina
Mäki, Tiina & Toivonen, Lauri & Koskinen, Pekka & Näveri, Hannu & Härkönen, Matti & Leinonen, Hannu
Effect of ethanol drinking, hangover, and exercise on adrenergic activity and heart rate variability in patients with a history of alcohol-induced atrial fibrillation.
American journal of cardiology 82 (1998) s. 317-322, imp.: 2.402

Tikkanen, Heikki O.
Tikkanen, Heikki O. & Hämäläinen, Esa & Sarna, Seppo & Adlercreutz, Herman & Härkönen, Matti
Associations between skeletal muscle properties, physical fitness, physical activity and coronary heart disease risk factors in men.
Atherosclerosis 137 (1998) s. 377-389, imp.: 2.889

Palotie, Aarno
Aaltonen, Johanna & Björses, Petra & Perheentupa, Jaakko & Horelli-Kuitunen, Nina & Palotie, Aarno & Peltonen, Leena
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains.
Nature genetics 17 (1997) s. 399-403, imp.: 31.473

Heiskanen, Mervi
Heiskanen, Mervi & Peltonen, Leena & Palotie, Aarno
Visual mapping by high resolution FISH.
Trends in genetics 12 (1996) : 10 s. 379-382, imp.: 10.11

Horelli-Kuitunen, Nina
Paavonen, Karri & Horelli-Kuitunen, Nina & Chilov, Dimitri & Kukk, Eola & Pennanen, Sari & Kallioniemi, Olli-Pekka & Pajusola, Katri & Olofsson, Birgitta & Eriksson, Ulf & Joukov, Vladimir & Palotie, Aarno & Alitalo, Kari
Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively.
Circulation 93 (1996) s. 1079-1082, imp.: 8.822

Ihalainen, Jarkko
Anttila, Pekka & Ihalainen, Jarkko & Salo, Armi & Heiskanen, Mervi & Juvonen, Eeva & Palotie, Aarno
Idiopathic macrocytic anaemia in the aged: molecular and cytogenic findings.
British journal of haematology 90 (1995) s. 797-803, imp.: 2.976

Kaukonen, Jaakko
Kaukonen, Jaakko & Lahtinen, Isto & Laine, Sinikka & Alitalo, Kari & Palotie, Aarno
BXM tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias.
British journal of haematology 94 (1996) s. 455-460, imp.: 2.568

Laan, Maris
Laan, Maris & Isosomppi, Juha & Klockars, Tuomas & Peltonen, Leena & Palotie, Aarno
Utilization of FISH in positional cloning: an example on 13q22.
Genome research 6 (1996) s. 1002-1012, imp.: 3.620

Laiho, Elina
Laiho, Elina & Ignatius, Jaakko & Mikkola, Hanna & Yee, Vivien & Teller, David & Niemi, Kirsti-Maria & Saarialho-Kere, Ulpu & Kere, Juha & Palotie, Aarno
Transglutaminase 1 mutations in autosomal recessive congenital ichthyosis: private and recurrent mutations in an isolated population.
American journal of human genetics 61 (1997) : 3 s. 529-538, imp.: 9.366

Mikkola, Hanna
Mikkola, Hanna & Muszbek, Laszlo & Laiho, Elina & Syrjälä, Martti & Hämäläinen, Eija & Haramura, Gizela & Salmi, Toivo & Peltonen, Leena & Palotie, Aarno
Molecular mechanism of a mild phenotype in coagulation factor XIII (FXIII) deficiency: a splicing mutation permitting partial correct splicing of FXIII A-subunit mRNA.
Blood : the journal of hematology 89 (1997) : 4 s. 1279-1287 , imp.: 9.745

Orpana, Arto
Orpana, Arto & Ranta, Varpu & Mikkola, Tomi & Viinikka, Lasse & Ylikorkala, Olavi
Inducible nitric oxide and prostacyclin productions are differently controlled by extracellular matrix and cell density in human vascular endothelial cells.
Journal of cellular biochemistry 64 (1997) s. 538-546, imp.: 3.471

Wartiovaara, Ulla
Wartiovaara, Ulla & Salven, Petri & Mikkola, Hanna & Lassila, Riitta & Kaukonen, Jaakko & Joukov, Vladimir & Orpana, Arto & Ristimäki, Ari & Heikinheimo, Markku & Joensuu, Heikki & Alitalo, Kari & Palotie, Aarno
Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation.
Thrombosis and haemostasis 80 (1998) s. 171-175, imp.: 4.582

Stenman, Ulf-Håkan
Stenman, Ulf-Håkan & Hakama, Matti & Knekt, Paul & Aromaa, Arpo & Teppo, Lyly & Leinonen, Jari
Serum concentrations of prostate specific antigen and its complex with alpha-antichymotrypsin before diagnosis of prostate cancer.
Lancet 344 (1994) s. 1594-1598, imp.: 15.888

Demir, And
Demir, And & Dunkel, Leo & Stenman, Ulf-Håkan & Voutilainen, Raimo
Age-related course of urinary gonadotropins in children.
Journal of clinical endocrinology and metabolism 80 (1995) s. 1457-1460, imp.: 4.22

Turpeinen, Ursula
Turpeinen, Ursula & Sipilä, Ilkka & Anttila, Pekka & Karjalainen, Ulla & Kuronen, Birgitta & Kalkkinen, Nisse & Ahola, Tapani & Stenman, Ulf-Håkan
Two Ó-chain hemoglobin variants, Hb broussais and Hb cemenelum, characterized by cation-exchange HPLC, isoelectric focusing, and peptide sequencing.
Clinical chemistry 41 (1995) : 4 s. 532-536, imp.: 2.355

Hedström, Johan
Hedström, Johan & Korvuo, Armi & Kenkimäki, Pirjo & Tikanoja, Sari & Haapiainen, Reijo & Kivilaakso, Eero & Stenman, Ulf-Håkan
Urinary trypsinogen-2 test strip for acute pancreatitis: [early reports].
Lancet 347 (1996) s. 729-731, imp.: 17.332

Leinonen, Jari
Leinonen, Jari & Zhang, Wan-Ming & Stenman, Ulf-Håkan
Complex formation between PSA isoenzymes and protease inhibitors.
Journal of urology 155 (1996) s. 1099-1103, imp.: 2.539

Itkonen, Outi
Itkonen, Outi & Stenman, Ulf-Håkan & Osman, Sirpa & Koivunen, Erkki & Halila, Hannu & Schröder, Tom
Serum samples from pancreatectomized patients contain trypsinogen immunoreactivity.
Journal of laboratory and clinical medicine 128 (1996) s. 98-102, imp.: 2.255

Alfthan, Henrik
Alfthan, Henrik & Stenman, Ulf-Håkan
Pathophysiological importance of various molecular forms of human choriogonadotropin.
Molecular and cellular endocrinology 125 (1996) s. 107-120, imp.: 2.599

Lintula, Susanna
Lintula, Susanna & Stenman, Ulf-Håkan
The expression of prostate-specific membrane antigen in peripheral blood leukocytes.
Journal of urology 157 (1997) s. 1969-1972, imp.: 2.668

Stenman, Jakob
Stenman, Jakob & Lintula, Susanna & Hotakainen, Kristina & Vartiainen, Juhani & Lehväslaiho, Heikki & Stenman, Ulf-Håkan
Detection of squamous-cell carcinoma antigen-expressing tumour cells in blood by reverse transcriptase-polymerase chain reaction in cancer of the uterine cervix.
International journal of cancer 74 (1997) s. 75-80, imp.: 3.534

Zhang, Wan-Ming
Zhang, Wan-Ming & Leinonen, Jari & Kalkkinen, Nisse & Stenman, Ulf-Håkan
Prostate-specific antigen forms a complex with and cleaves alpha-1-protease inhibitor in vitro.
Prostate 33 (1997) s. 87-96, imp.: 2.552

Kemppainen, Esko
Kemppainen, Esko & Hedström, Johan & Puolakkainen, Pauli & Sainio, Vesa & Haapiainen, Reijo & Perhoniemi, Vesa & Osman, Sirpa & Kivilaakso, Eero & Stenman, Ulf-Håkan
Rapid measurement of urinary trypsinogen-2 as a screening test for acute pancreatitis.
New England journal of medicine 336 (1997) : 25 s. 1788-1793, imp.: 24.834

Vartiainen, Juhani
Vartiainen, Juhani & Alfthan, Henrik & Lehtovirta, Pentti & Stenman, Ulf-Håkan
Identification of choriocarcinoma by the hCG beta-to-hCG proportion in patients with delayed diagnosis caused by contraceptive use.
Contraception : an international journal 57 (1998) s. 257-260, imp.: 1.061

Finne, Patrik
Zhang, Wan-Ming & Finne, Patrik & Leinonen, Jari & Vesalainen, Satu & Nordling, Stig & Rannikko, Sakari & Stenman, Ulf-Håkan
Characterization and immunological determination of the complex between prostate-specific antigen and alpha2-macroglobulin.
Clinical chemistry 44 (1998) s. 2471-2479, imp.: 3.703

Kairemo, Kalevi J. A.
Kairemo, Kalevi J. A. & Jekunen, Antti & Ramsay, Hans & Tagesson, Magnus & Liewendahl, Kristian & Jääskelä-Saari, Hilkka & Paavonen, Timo & Ljunggren, Kaj & Savolainen, Sauli & Strand, Sven-Erik
Indium-111 bleomycin complex for radiochemotherapy of head and neck cancer - dosimetric and biokinetic aspects.
European journal of nuclear medicine 23 (1996) : 6 s. 631-638, imp.: 2.69

Karjalainen, Ulla
Karjalainen, Erkki J. & Karjalainen, Ulla
Data analysis for hyphenated techniques.
Amsterdam : Elsevier Science, 1996. (Data handling in science and technology; vol. 17). 475 s. + Spectrum extraction from hyphenated data: MATLAB TM programs and sample data [CD-ROM ].

Karonen, Sirkka-Liisa
Rönnemaa, Tapani & Karonen, Sirkka-Liisa & Rissanen, Aila & Koskenvuo, Markku & Koivisto, Veikko
Relation between plasma leptin levels and measures of body fat in identical twins discordant for obesity.
Annals of internal medicine 126 (1997) : 1 s. 26-31, imp.: 11.21

Liewendahl, Kristian
Löfberg, Mervi & Liewendahl, Kristian & Savolainen, Sauli & Nikkinen, Päivi & Tiula, Eero & Somer, Hannu & Lamminen, Antti
Antimyosin scintigraphy in patients with acquired and hereditary muscular disorders.
European journal of nuclear medicine 21 (1994) : 10 s. 1098-1105

Nikkinen, Päivi
Sipilä, O. & Nikkinen, Päivi & Pohjonen, Hanna & Poutanen, Veli-Pekka & Visa, A. & Savolainen, Sauli & Katila, Toivo & Liewendahl, Kristian
Accuracy of a registration procedure for brain SPET and MRI: phantom and simulation studies.
Nuclear medicine communications 18 (1997) s. 517-526, imp.: 0.888

Syrjälä, Martti
Mikkola, Hanna & Yee, Vivien C. & Syrjälä, Martti & Seitz, Rainer & Egbring, Rudolf & Petrini, Pia & Ljung, Rolf & Ingerslev, Jorgen & Teller, David C. & Peltonen, Leena & Palotie, Aarno
Four novel mutations in deficiency of coagulation factor XIII: consequences to expression and structure of the A-subunit.
Blood 87 (1996) : 1 s. 141-151, imp.: 8.279

Uotila, Lasse
Uotila, Lasse & Koivusalo, Martti
Expression of formaldehyde dehydrogenase and S-formylglutathione hydrolase activities in different rat tissues.
Advances in experimental medicine and biology 414 (1997) s. 365-371

Viinikka, Lasse
Laivuori, Hannele & Kaaja, Risto & Rutanen, Eeva-Maria & Viinikka, Lasse & Ylikorkala, Olavi
Evidence of high circulating testosterone in women with prior preeclampsia.
Journal of clinical endocrinology and metabolism 83 (1998) : 2 s. 344-347, imp.: 4.575


CLINICAL PHARMACOLOGY

Ph.D. Thesis (12) from the Department of Clinical Pharmacology (years 1994-1998)

Kuitunen Tapio: The clinical test for drunkenness in evaluating the effects of drugs on driving fitness: comparison with psychomotor laboratory tests, pp. 1-74, Yliopistopaino, Helsinki 1994 (ISBN 952-90-6056-4)

Backman Janne: The effects of drugs inhibiting and inducing CYP3A enzymes on the pharmacokinetics and pharmacodynamics of oral midazolam, pp.1-52 . Hakapaino Oy, Helsinki 1995 (ISBN 952-90-7121-3)

Laaksonen Reijo:The effect of HMG-CoA reductase inhibitor treatment on serum and skeletal muscle ubiquinone, pp.1-46. Helsinki 1996 (ISBN 952-90-7220-1)

Luurila Harri: Effect of erythromycin on the pharmacokinetics and pharmacodynamics of hypnotics, pp. 1-62. Helsinki 1996 (ISBN 952-90-7496-4)

Varhe Anu: Interactions of triazolam with inhibitors of CYP3A enzymes, pp. 1-63. Helsinki 1996 (ISBN 952-90-7896-2)

Ahonen Jouni: Studies on CYP3A mediated drug interactions in anaesthesiology, pp.1-82. Helsinki 1996 (ISBN 952-90-8064-6)

Hämäläinen Mirja: Optimal drug treatment of recurrent headaches and migraine in children - a clinical and pharmacological study, pp. 1-101. Helsinki 1997 (ISBN 952-90-8490-0)

Illi Ari: Inhibition of catechol-O-methyltransferase by entacapone: Effects on haemodynamics and catecholamine metabolism and interactions with drugs interfering with catecholamine disposition, pp. 1-51. Helsinki 1997 (ISBN 952-90-8429-X)

Kähkönen Seppo: Pharmacodynamic and pharmacokinetic aspects of propranolol, varapamil and isosorbide dinitrate during alcohol withdrawal, pp. 1-107. Helsinki 1997 (ISBN 952-90-8422-6)

Lukkari Eeva: Clinical pharmacology of oxybutynin, with special reference to pharmacokinetics and interaction, pp. 1-50. Helsinki 1997 (ISBN 952-90-9399-3)

Kaukonen K-M: Studies on the effects of a CYP3A4-inhibitor, itraconazole, on the pharmacokinetics and pharmacodynamics of cardiovascular drugs, pp. 1-69. Helsinki 1997 (ISBN 952-90-9381-0)

Lamberg Tommi: Effects of inhibition and induction of CYP3A4 on the pharmacokinetics and pharmacodynamics of buspirone, pp. 1-79. Helsinki 1998 (ISBN 952-91-0602-5)

Original articles:

Backman Janne T, Olkkola KT, Aranko Kari, Himberg Jaakko-Juhani, Neuvonen Pertti J: Dose of midazolam should be reduced during diltiazem and verapamil treatments. Br J Clin Pharm 1994:37;221-225.

Olkkola KT, Backman Janne T, Neuvonen Pertti J: Midazolam should be avoided in patients receiving systemic antimycotics ketokonazole or itrakonazole. Clin Pharm Ther 1994:55;481-485.

Varhe Anu, Olkkola KT, Neuvonen Pertti J: Oral triazolam potentially hazardous to patients receiving systemic antimycotics ketokonazole or itraconazole. Clin Pharmacol Ther 1994:56;601-607.

Laaksonen Reijo, Jokelainen K, Sahi T, Tikaknen MJ, Himberg Jaakko-Juhani: Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in man. Clin Pharmacol Ther 1995:57:62-66.

Ahonen J, Olkkola KT, Salmenperä M, Hynynen M, Neuvonen Pertti J: Effect of diltiazem on midazolam and alfentanil disposition in patients undergoing coronary arterybypass grafting. Anesthesiology 1996;85:1246-52.

Backman Janne T, Olkkola KT, Neuvonen Pertti J: Rifampin drastically reduces plasma concentrations and effects od oral midazolam. Clin Pharmacol Ther 1996:59:7-13.

Backman Janne T, Olkkola KT, Neuvonen Pertti J: Concentrations and effects of oral midazolam are greatly reduced in patients treated with carbamazepine or phenytoin. Epilepsia 1996:37:253-7.

Illi Ari, Sundberg S, Ojala-Karlsson P, Scheinin M, Gordin A: Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: Effects on hemodynamics and catecholamine metabolism in healthy volunteers. Clin Pharmacol Ther 1996:59:450-7.

Kalso E, Tasmuth T, Neuvonen Pertti J: Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer. Pain 1996 (5):64:293-302.

Laaksonen Reijo, Jokelainen K, Laakso J, Sahi T, Härkönen M, Tikkanen MJ, Himberg Jaakko-Juhani: The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle. Am J Cardiol 1996:77:851-854.

Neuvonen Pertti J, Jalava Maija: Itraconazole drastically increases plasma concentrations of lovastatin acid. Clin Pharmacol Ther 1996:60:54-61.

Varhe Anu, Olkkola KT, Neuvonen Pertti J: Diltiazem enhances the effects of triazolam by inhibiting its metabolism. Clin Pharmacol Ther 1996:59:369-95.

Hämäläinen Mirja L, Hoppu K, Valkeila E, Santavuori P: Ibuprofen or acetaminophen for the acute treatment of migraine in children: A double-blind, randomized, placebo-controlled, crossover study. Neurology 1997:48:103-7.

Jalava Kirsi-Maija, Olkkola KT, Neuvonen Pertti J: Itraconazole greatly increases plasma concentrations and effects of felodipine. Clin Pharmacol Ther 1997:61:410-5.

Kaukonen Kirsi-Maija, Olkkola KT, Neuvonen Partti J: Itraconazole increases plasma concentrations of quinidine. Clin Pharmacol Ther 1997:62:510-17.

Kivistö Kari T, Lamberg Tommi S, Kantola Teemu, Neuvonen Pertti J: Plasma buspirone concentrations are greatly increased by erythromycin and itraconazole. Clin Pharmacol Ther 1997:62:348-54.

Sarna S, Hoppu K, Neuvonen Pertti J, Laine J, Holmberg C: Methylprednisolone exposure rather than the dose predicts adrenal suppression and growth inhibition in children with liver and renal transplants. J Clin Endocrin and Metab 1997:82:75-78.

Villikka Kirsti, Kivistö Kari T, Backman Janne T, Olkkola KT, Neuvonen Pertti J: Triazolam is ineffective in patients taking rifamoin. Clin Pharmacol Ther 1997:61:8-14.

Kantola Teemu, Kivistö Kari T, Neuvonen Pertti J: Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. Clin Pharmacol Ther 1998:63:397-402.

Kivistö Kari T, Villikka Kirsti, Nyman L, Anttila M, Neuvonen Pertti J: Tamoxifen and toremifene concentrations in plasma are greatly decreased by rifambin. Clin Pharmacol Ther 1998:64:648-54.

Lamberg Tommi S, Kivistö Kari T, Neuvonen Pertti J: Effects of verapamil and diltiazem on the pharmacokinetics and pharmacodynamics of busbirone. Clin Pharmacol Ther 1998:63:640-5.

Lilja Jari, Kivistö Kari T, Backman Janne T, Lamberg Tommi S, Neuvonen Pertti J: Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors. Clin Pharmacol Ther 1998:64:477-83.

Neuvonen Pertti J, Kantola Teemu, Kivistö Kari T: Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole. Clin Pharmacol Ther 1998:63:332-41.

Varis Tiina, Kaukonen Kirsi-Maija, Kivistö Kari T, Neuvonen Pertti J: Plasma concentrations and effects of oral methylprednisolone are considerably increased by itraconazole. Clin Pharmacol Ther 1998:64:363-8.


RADIOLOGY

Halavaara J, Lamminen A, Bondestam S, Standertskjöld-Nordenstam C-G: Detection of focal liver lesions with superparamagnetic iron oxide: value of STIR and SE imaging. J Comp Ass Tomogr 1994: 18:897-904.

Aronen HJ, Gazit IE, Louis DN & al.: Cerebral volume map of gliomas: comparison with tumor grade and histologic findings. Radiology 1994: 191: 41-51.

Sainio V, Kemppainen E,…Taavitsainen M, Kivisaari L & al.: Early antibiotic treatment in acute necrotizing pancreatitis. Lancet 1995: 346: 663-6. IF 15.888

Korvenoja A, Wikström H, Huttunen J….Aronen HJ & al.: Activation of ipsilateral primary sensorimotorcortex by median nerve stimulation. NeuroReport 1995: 6: 2589-93. IF 2.277.

Markkola A, Aronen HJ, Paavonen T & al.: Spin lock and magnetization transfer imaging of head and neck tumors. Radiology 1996: 200: 369-75.

Autti T, Santavuori P, Raininko R & al.: Bone marrow transplantation in aspartylglucosaminuria. Lancet 1997: 349: 1366-7. IF 15.888

Autti T, Sipilä L, Autti H, Salonen O: Brain lesions in contact sports. Lancet 1997: 349:1142. IF 15.888

Mäntylä R, Erkinjuntti T, Salonen O, Aronen HJ,… Standertskjöld-Nordenstam C-G: Variable agreement between visual rating scales for white matter hyperintensities on MRI. Comparison of 13 rating scales in a post-stroke cohort. Stroke 1997: 28: 1614-23.

Tukeva TA, Aronen HJ, Karjalainen P& al.: MR imaging in pelvic inflammatory disease: comparison with laparoscopy and US. Radiology 1998: 210: 209-16.

Joensuu RP, Sepponen R, Lamminen A, Savolainen S, Standertskjöld-Nordenstam C-G: High-accuracy MR tracking of interventional devices: The Overhauser marker enhancement (OMEN) technique. Magn Res Med 1998: 40:914-21.

Ikonen S, Kärkkäinen P, Kivisaari L, Salo J, Taari K, Vehmas T, Tervahartiala P, Rannikko S: Magnetic resonance imaging of clinically localized prostatic cancer. J Urol 1998: 159: 915-19.

Tiihonen J, Katila H….Aronen HJ,….Salli E, Karhu J: Reversal of cerebral asymmetry in schizophrenia measured with magnetoencephalography. Schizophrenia Res 1998: 30:209-19.




CLINICAL PHYSIOLOGY